A latest examine from UiB exhibits that elevated plasma methylmalonic acid predicts elevated danger of acute myocardial infarction and mortality in sufferers with suspected or verified coronary coronary heart illness.
Methylmalonic acid (MMA) is a substance produced from the breakdown of aminoacids, odd-chain fatty acids and ldl cholesterol within the physique. MMA focus in blood is reported to be elevated in sufferers with coronary heart illnesses and kidney impairment, and better plasma MMA is taken into account a marker of vitamin B12 deficiency.
In our examine, we analyzed the affiliation of plasma MMA with the danger of acute myocardial infarction and dying in 7662 members of two massive, unbiased cohorts of sufferers evaluated for both suspected coronary coronary heart illness or verified coronary coronary heart illness.”
Indu Dhar, lead writer of article, researcher, Division of Scientific Science, College of Bergen
They discovered that throughout each cohorts greater MMA in plasma was related to diminished renal perform and low B12 standing at baseline. Nonetheless, greater plasma MMA predicted elevated long-term danger of acute myocardial infarction and complete and cardiovascular deaths unbiased of renal perform and B12 standing.
“This will counsel that danger relationship between MMA and outcomes is just not defined by vitamin B12 standing or kidney perform alone2, says Dhar.
One other necessary discovering findings from this analysis was the constructive affiliation between plasma MMA and danger of dying as a consequence of non-cardiovascular causes primarily in sufferers evaluated for suspected coronary coronary heart illness, thus warranting additional analysis to discover MMA in a wider perspective past cardiovascular illnesses.
“Future research also needs to examine the potential position of MMA as an necessary regulator of vitality and lipid metabolism”, Dhar concludes.
Dhar, I., et al. (2023) Plasma methylmalonic acid predicts danger of acute myocardial infarction and mortality in sufferers with coronary coronary heart illness: A potential 2-cohort examine. Journal of Inner Medication. doi.org/10.1111/joim.13610.